Additional Responsibility
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Dean, Research and Development
Publications All
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A Three-Component Synthesis of Spiropyrrolines
Sahoo, K., Patra, N., Dandela, R., Thirupathi, B.
Total Synthesis and Determination of the Absolute Configuration of Berkeleylactone I
Mandal, S., Mahananda, D., Paladugu, D., Thirupathi, B.
Total Synthesis, Revised Structure, and Biological Evaluation of Elgonene B and Analogues
Mandal, S., Mahananda, D., Dey, S., Bharathavikru, R.S., Thirupathi, B.
Synthesis of Highly Functionalized Spirocycles and Pentafulvene-Containing Dyes Involving 2-(2?-ketoalkyl)-1,3-indandiones
Mishra, G., Sasmal, M., Chakraborty, A., Thirupathi, B.
Cascade Nucleophilic Addition-Cyclic Michael Addition of Arynes and Indoles Bearing Michael Acceptor: A Strategy to Construct Pyrroloacridines and Study of Their Physicochemical Properties
Hazra, G., Kundu, S., Dandela, R., Thirupathi, B.
Recent advances with cobalt-mediated asymmetric hydrogenations
Hazra, G., Dinesh, S., Sahoo, K., Thirupathi, B.
Synthesis of Fluorinated 2-Benzylphthalazin-1(2 H)-one, 1-Phthalazinamine, and 1-Alkoxy/Benzyloxyphthalazine Derivatives by an Ultrasonication Method
Pothireddy, M., Hazra, G., Babu, P.V., Thirupathi, B., Dandela, R.
A Method to Access Highly Functionalized Dibenzobicyclo[3.2.1]octadienones: Application to the Construction of the 6/6/5/6/6 Carbon Skeleton of Rubialatin A
Hazra, G., Mishra, G., Dandela, R., Thirupathi, B.
Total synthesis of proposed elgonene C and its (4R,5R)-diastereomer
Mandal, S., Thirupathi, B.
Synthetic method to access fluorinated 2-benzylpyridines by using Negishi coupling reaction
Pothireddy, M., Bhukta, S., Babu, P.V., Thirupathi, B., Dandela, R.
Strategies for the construction of ?-spirocyclic butenolides in natural product synthesis
Mandal, S., Thirupathi, B.
Syntheses and Biological Importance of Herboxidiene/GEX1A
Thirupathi, B., Zilla, M.K.
Total Synthesis of (+)-Sacrolide A
Thirupathi, B., Jena, B.K.
Academic Background
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M.Sc. (Organic Chemistry) Osmania University, 2006-2008
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PhD.: CSIR-Indian Institute of Chemical Technology, Hyderabad, 2009-2014
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Postdoctoral studies: Harvard University, Cambridge, USA, Advisor: Prof. E. J. Corey, 2015-2018.
Professional Experience
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Associate Professor: Department of Chemical Sciences, IISER Berhampur, Feb. 2024-Present.
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Assistant Professor: Department of Chemical Sciences, IISER Berhampur, July 2018 - Feb. 2024.
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Associate Research Scientist, Sai Life Sciences, Hyderabad, India; March 2014-Feb. 2015.
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Research Chemist, Aragen Life Sciences Formerly Known as GVK BIO Sciences, Hyderabad, India; May 2008-March 2009.
Awards and Memberships
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Thieme Chemistry Journal Award-2023
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Postdoctoral fellowship from Harvard University, USA, 2015-2018
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Senior Research Fellowship, CSIR-UGC; 2011-2014. Junior Research Fellowship, CSIR-UGC; 2009-2011
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Best performance award from Aragen Life Sciences formerly known as GVK-Biosciences in 2009
Research Interests
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Organic Synthesis
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Total Synthesis of Natural Products
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Aryne Chemistry
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Asymmetric Synthesis
Research Group
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Mr. Sudip Mandal PhD Scholar; (2019-2024)
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Ms. Gitanjali Mishra (2020-Till date) Mr. Sayantan Kundu, iPhD (2022-Till date) Mr. Nityaprakash PhD Scholar (2022-Till date) Mr. Biral Kanti Pal, PhD Scholar (2022-Till date)
About me
Through his research, teaching, and publications, Dr. Barla is a committed, knowledgeable, and capable researcher. He has developed a solid reputation among students and colleagues alike. He has over 15 years of research experience in synthetic organic and medicinal chemistry. He worked in various pharmaceutical industries in process and medicinal chemistry, which shaped him into a successful researcher in synthetic chemistry and related areas.
Biography
Dr. Barla Thirupathi was born in Madavelli, Manchirial district, Telangana, India in 1984. After completing his M.Sc. (Organic Chemistry) from Osmania University (2006-2008), he worked as a research chemist at Aragen Life Sciences, formerly known as GVK-Biosciences, Hyderabad (2008-2009). In early 2009, he joined as a Junior Research Fellow (JRF) at CSIR-Indian Institute of Chemical Technology, Hyderabad, with Dr. Debendra K. Mohapatra for his doctoral studies (2009-2014). Afterwards, he worked as an associate research scientist in the process R&D division at Sai Life Sciences, Hyderabad (2014-2015). Then Dr. Thirupathi moved to Harvard University as a postdoctoral fellow to work with Nobel laureate Prof. E. J. Corey (2015-2018), where he worked on the development of highly active fluorinated second-generation oxazaborolidine catalysts and their application in enantioselective Diels-Alder reactions. In July 2018, he moved back to India and joined as an assistant professor of chemistry at one of India's premier institutes, the Indian Institute of Science Education and Research (IISER) Berhampur. Dr. Thirupathi has already been recognized as an upcoming independent researcher and has endowed various accolades, including the 2023 Thieme Chemistry Journals Award.
Key Publications
2024
27. Synthesis and Functionalization of Natural Products with Light-Driven Reactions Sahoo, K.; Mishra, G.; Thirupathi, B*. Publisher: John Wiley, Sustainable Green Catalytic Processes, 2024, 183 DOI: 10.1002/9781394212767.ch9 Book chapter, ISBN: 9781394212552, .
26. Synthesis of Spirocyclic-1,3-indandione Containing-Cyclopentenones and -Benzotropones, Mishra, G.; C. M, Y., Thirupathi, B*. Chemistry An Asian Journal, 2024, Accepted article, Doi: 10.1002/asia.202400667
25. A Three-Component Synthesis of Spiropyrrolines, Sahoo, K.; Patra, N.; Dandela, R. Thirupathi, B*. The Journal of Organic Chemistry. 2024, 89, 5337–5352.
24. Total Synthesis and Determination of the Absolute Configuration of Berkeleylactone I: Sudip, M.; Dora, M.; Dileep, P.; Thirupathi, B*. The Journal of Organic Chemistry. 2024, 89, 4165–4175.
23. Synform Interview of Barla Thirupathi as a Young Career Focus Presentation: DOI: 10.1055/s-0040-1720624 Synform 2024/03, A41–A43
2023
22. Total Synthesis, Revised Structure, and Biological Evaluation of Elgonene B and Analogues. Sudip M., Dora M., Sourav D., Ruthrotha S. B., Thirupathi, B.* Journal of Natural Products, 2024, 87, 152–159.
21. Synthesis of Highly Functionalized Spirocycles and Pentafulvene Containing Dyes Involving 2-(2'-ketoalkyl)-1,3-indandiones. Mishra, G.; Sasmal, M.; Chakraborty, A.; Thirupathi, B.* Chemistry—A European Journal, 2023, e202301976 (Featured on the journal cover page).
20. Cascade Nucleophilic Addition-Cyclic Michael Addition of Arynes, Indoles Bearing Michael Acceptor: A Strategy To Construct Pyrroloacridines, and Study of Their Physicochemical Properties. Hazra, G.; Kundu, S.; Dandela, R.; Thirupathi, B.* The Journal of Organic Chemistry 2023, 88, 8493–8504.
2022
18. Synthesis of Fluorinated 1-(2-Benzyl)-phthalazinone, 1-Phthalazinamine, and 1-Alkoxy/Benzyloxy-Phthalazine Derivatives by Ultrasonication Method (Invited article for the Special Issue on Chemical Synthesis and Catalysis in India), Pothireddy, M.; Gurupada, H.; Vijaya Babu, P.; Thirupathi, B.*; Rambabu. D.* Synlett 2022; 33(17): 1716-1722.
17. A Method to Access Highly Functionalized Dibenzobicyclo[3.2.1]octadienones: Application to the Construction of the 6/6/5/6/6 Carbon Skeleton of Rubialatin A . Hazra, G.; Mishra, G.; Dandela, R.; Thirupathi, B.* The Journal of Organic Chemistry 2022, 87, 18, 11925-11938 (Selected and featured on the journal front cover of the issue).
16. Total Synthesis of Proposed Elgonene C and its (4R,5R)-Diastereomer Sudip M., Thirupathi, B.* Org. Biomol. Chem., 2022, 20, 3922-3929. (Selected and featured on the journal front cover of the issue).
15. Synthetic method to access fluorinated 2-benzylpyridines by using Negishi coupling reaction. Pothireddy, M.; Bhukta, S.; Vijaya Babu, P.; Thirupathi, B*.; Rambabu. D*. Synthetic Communications. 2022, 1-13.
2020
14. Strategies for the Construction of γ-Spirocyclic Butenolides in Natural Product Synthesis. Sudip M., Thirupathi, B.* Org. Biomol. Chem., 2020, 18, 5287-5314.
13. Syntheses and Biological Importance of Herboxidiene/GEX1A. Thirupathi, B*.; Zilla, M. K. ChemistrySelect. 2019, 4, 11944-11958.
2019
Total Synthesis of (+)-Sacrolide-A
(Thirupathi, B*.; Jena, B, K.* ChemistrySelect. 2019, 4, 2908-2911)
(Top downloaded article among work published between January 2018 and December 2019 in its journal)Contact Details
Full Name
Thirupathi Barla
Email
thirupathibarla@iiserbpr.ac.in
Contact
0680 2227762
Address
IISER Berhampur
Personal Website
https://bthirupathi56.wixsite.com/website