• Mannar, D*., Saville, J. W*., Zhu, X*., Srivastava, S. S., Berezuk, A. M., Zhou, S., Tuttle, K. S.,Marquez, C., Sekirov, I., and Subramaniam, S. (2021) SARS-CoV-2 Omicron Variant: ACE2 Binding, Cryo-EM Structure of Spike Protein-ACE2 Complex and Antibody Evasion. Science 375,760–764.
• Zhu, X*., Mannar, D*., Srivastava, S. S*., Berezuk, A*. M., Demers, J. P., Saville, J. W., Leopold, K., Li, W., Dimitrov, D. S., Tuttle, K. S., Zhou, S., Chittori, S., and Subramaniam, S. (2021) Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies PLOS Biology 19(4):e3001237. Equal first author.
• Srivastava, S. S*., Darling, J. E*., Suryadi, J., Morris, J. C., Drew, M. E., and Subramaniam, S. (2020) Plasmodium vivax and human hexokinases share similar active sites but display distinct quaternary architectures. IUCrJ 7, 453-461 Featured on the cover page. Equal first author.
• Srivastava, S. S., Jamkhindikar, A. A., Raman, R, Jobby, M. K., Chadalawada, S., Sankaranarayanan, R. and Sharma, Y. (2016) A transition metal–binding, trimeric βγ-crystallin from methane producing thermophilic archaea Methanosaeta thermophila. Biochemistry 56, 1299-1310. Featured on the cover page.
• Srivastava, S. S*., Raman, R*. , Kiran, U. , Garg, R. , Chadalawada, S. , Pawar, A. D., Sankaranarayanan, R. and Sharma, Y. (2018) Interface interactions between βγ‐crystallin domain and Ig‐like domain render Ca2+‐binding site inoperative in Abundant Perithecial Protein of Neurospora crassa. Molecular Microbiology. 110, 955-972. Featured on the cover page. Equal first author

Molecular interactions control every aspect of cellular function. Therefore, decoding protein-protein, protein-nucleic acid, and protein-ligand interactions is critical for comprehending any cellular event. Knowing how these interactions are perturbed in various disease conditions is crucial for developing effective therapeutics and drugs. To gain such molecular insights, multiple high-resolution structures of various macromolecular complexes are required. Therefore, along with conventional molecular biology, biochemistry, and biophysical techniques, we employ cryo-electron microscopy (cryo-EM) and X-ray crystallography to determine atomic or near-atomic structures. With this, we aim to advance the structural knowledge crucial to comprehending the biophysical and biochemical aspects of protein structure and function. Current projects in the lab as as follows:

1: Elucidating the molecular design principles underlying variable substrate recruitment by PP2A holoenzymes.

2:Understanding the role of protein-protein interactions in the bacterial innate immune system using single-particle cryo-electron microscopy.

3:Structural biology of signal transmission and epigenetic gene regulation.

• Single particle cryo-electron microscopy, X-ray crystallography, Biophysics, Drug discovery

• Rohit Sen, PhD Student
• Hiranmoy Adak, PhD Student
• Subhangi Subudhi, PhD Student
• Sharadhha Dhuware, Project JRF
• Siddhant Raj Naik, BSMS Student
• Shashank Raj , BSMS Student
• Huda Abdul Jaleel, BSMS Student

• Ph.D. (2016): CSIR-Centre for Cellular and Molecular Biology (CCMB), Hyderabad, India
• M.Sc. (2007) : School of Biotechnology, Jawaharlal Nehru University, New Delhi, India
• B.Sc. (2005): Banaras Hindu University, Varanasi, India

• Assistant Professor : Department of Biological Sciences, Indian Institute of Science Education and Research (IISER), Berhampur, India
• Postdoctoral Fellow (2019-2022): Faculty of Medicine, University of British Columbia (UBC), Vancouver, Canada
• Postdoctoral Visiting Fellow (2018-2019): National Cancer Institute (NCI), National Institutes of Health(NIH), USA.
• Post-Ph.D. work (2016-2018): CSIR-Centre for Cellular and Molecular Biology (CCMB), Hyderabad, India

• Ramalingaswami Re-entry Fellowship, Department of Biotechnology, Ministry of science and technology, Government of India.
• Fulbright-Nehru Postdoctoral Research Fellowship (2018 -2019).
• Supplemental Visiting Fellow Award (SVFA) Fellowship, NCI, NIH, USA (2018-2019).
• Ratna Phadke Award for a young scientist from the Indian Biophysical Society (2017).
• Junior and Senior Research Fellowships from the Council of Scientific and Industrial Research(CSIR), India.
• Scholarship, Department of Biotechnology (D.B.T.), Government of India.
• National Scholarship during Intermediate (10+2).