Dr. Prosenjit Mondal obtained his
PhD degree from the Institute of Life Sciences, Bhubaneswar. He has been
a postdoctoral associate at Johns Hopkins University and Weill Medical College of Cornell University. Before joining IISER Berhampur, he was an Associate Professor at IIT Mandi. Hussain,
M, P.Mondal, Song, W. “Hepatic Kisspeptin secretion impairs insulin
secretion from pancreatic beta cell Kisspeptin receptor GPR54 antagonist
for treatment of prediabetes and diabetes mellitus in humans”. United
States patent no. 10,220,069 , Patent File date 22/7/2016, Patent Issue
date: 5/3/2019. G Dey,
P.Mondal, S. Ghosh. Compounds for visualization and quantification of
Albumin, method of preparation and use thereof Indian Patent No. :
342426 , Patent Filing date: 01/02/2017, Patent Issue date: 27/6/2020. K
Girdhar, P Gaur, and P Mondal -Patent title “A Non-peptidic
Glucagon-Like Peptide-1 Receptor Agonists for Anti-obesity and
Anti-diabetes Therapeutics” Indian Patent No 505134 , date of filling
29/11/2018 and international application No. PCT/IN2019/050874.Research Patents
P Rawat, S Thakur, K Jaswal, A Sen, A Biswal, B Dehury, P Mondal* (2026) Intermediate filament protein Vimentin propels intrahepatic lipid accumulation in insulin-resistant mice. Journal of Biological Chemistry, 113265 *Corresponding Author.
S Thakur, P Rawat, B Dehury, P Mondal* (2025) TRIM32 regulates insulin sensitivity by controlling insulin receptor degradation in the liver. EMBO reports, 1-19
A Sen, S Thakur, P Rawat, K Jaswal, B Dehury, P Mondal* (2025) Hepatic ChREBP reciprocally modulates systemic insulin sensitivity in NAFLD Journal of Biological Chemistry.108556
P Rawat, S Thakur, S Dogra, K Jaswal, B Dehury, P Mondal*(2023) Diet-induced induction of hepatic Serine/Threonine Kinase STK38 triggers proinflammation and hepatic lipid accumulation Journal of Biological Chemistry, 104678
S Dogra, D Das, SK Maity, A Paul, P Rawat, PV Daniel, K. Das, S. Mitra, P.Chakraborty*, P.Mondal* (2022) Liver Derived S100A6 Propels β Cell Dysfunction in NAFLD. Diabetes 71 (11), 2284-2296.
K Girdhar, S Thakur, P Gaur, A Choubey, S Dogra, B Dehury, S Kumar, B Biswas, D K Dwivedi, S Ghosh, P Mondal* (2022) Design, synthesis, and biological evaluation of a small molecule oral agonist of the glucagon-like-peptide-1 receptor Journal of Biological Chemistry 01889.
PV Daniel, A Choubey, S Dogra, P Rawat, A S Khan, S Rajak, M Kamthan, P Mondal* (2021) NF-kB P65 regulates hepatic lipogenesis by promoting nuclear entry of ChREBP in response to a high carbohydrate diet.Journal of Biological Chemistry: 100714.
Choubey A, Girdhar K, Kar AK, Kushwaha S, Yadav MK, Ghosh D, P Mondal*. (2020) Low dose naltrexone rescues inflammation and insulin resistance associated with hyperinsulinemia Journal of Biological Chemistry 27;295(48):16359-16369
Vineeth Daniel P, Kamthan M, Gera R, Dogra S, Gautam K, Ghosh D, P Mondal* (2019) Chronic exposure to Pb2+ perturbs ChREBP transactivation and coerces hepatic dyslipidemia. FEBS Letters. 593 (21), 3084-3097
Dogra S, Kar AK, Girdhar K, Daniel PV, Chatterjee S, Choubey A, Ghosh S, Patnaik S, Ghosh D, P.Mondal*. (2019) Zinc oxide nanoparticles attenuate hepatic steatosis development in high-fat-diet fed mice through activated AMPK signaling axis. Nanomedicine: Nanotechnology, Biology and Medicine 17: 210-222
WJ. Song#, P. Mondal#, A Wolfe, L C.Alonso, et al (2014) Glucagon regulates hepatic kisspeptin to impair insulin secretion in diabetes mellitus. Cell Metabolism 19(4):667–681 #Joint First Author
WJ. Song#, P. Mondal#,YY Li, SE Lee, MA. Hussain (2013) Pancreatic beta-cell response to increased metabolic demand and pharmacologic secretagogues requires EPAC2A Diabetes 62(8):2796-2807 #Joint First Author
Martinez BA, Reis Rodrigues P, Nuñez Medina RM, P Mondal, et. al (2020) An alternatively spliced, non- signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans. Elife Feb 25; 9: e49917.
M L. Multhaup, M Seldin, A E. Jaffe, H Kirchner, X Lei, P Mondal, et al (2015) Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes. Cell Metabolism 21(1) 138-149
P. Mondal#, W.J Song#, YY Li, K.S. Yang, M. A. Hussain (2015) Increasing beta-cell mass requires additional stimulation for adaptation to secretory demand. Molecular Endocrinology 29(1)108-120 #Joint First Author
WJ. Song, M. Seshadri, U. Ashraf, T. Mdluli, P. Mondal, et al. (2011) Snapin mediates incretin action and augments glucose-ependent insulin secretion. Cell Metabolism. 13(3):308-319.
S Diani-Moore, P Ram, X Li, P Mondal, DY Youn, AA Sauve, AB Rifkind (2010) Identification of the Aryl Hydrocarbon Receptor Target Gene TiPARP as a Mediator of Suppression of Hepatic Gluconeogenesis by 2,3,7,8-Tetrachlorodibenzo-p-dioxin and of Nicotinamide as a Corrective Agent for This Effect Journal of Biological Chemistry 285(50) 38801-38810
Our lab is dedicated to unraveling the complex pathogenesis of diabetes and NAFLD, emphasizing the crucial mechanisms of inter-organ communication that maintain systematic homeostasis in the body. Our research also delves into the molecular events that regulate nutrient uptake and storage, particularly focusing on the specificity of insulin's actions and the intricate links between obesity and diabetes. This work is of significant importance in the field of metabolic diseases.
Our studies cover
a wide spectrum of questions and use diverse methodologies for analysis. We
employ in vitro cell culture and in vivo mice models to understand the
inter-organ crosstalk between the liver, pancreatic beta cell, and peripheral
organs that contribute to the pathogenesis of diabetes, fatty liver, and
obesity. By studying the mechanisms of interorgan crosstalk in health and
disease, we aim to understand how preclinical evidence for organokines may translate to
human studies.
